Pathological examination of dementia with Lewy bodies patients identified the presence of
abnormal α-synuclein (αSyn) aggregates in the presynaptic terminals. αSyn is involved in
the regulation of soluble N-ethylmaleimide-sensitive factor attachment protein receptor
(SNARE) complex. Importantly, αSyn-transgenic mouse and postmortem examination of
patients with Parkinson's disease have demonstrated the abnormal distribution of SNARE
protein in presynaptic terminals. In this study, we investigated the effects of SNARE …

CiNii 博士論文 - Accumulation of α-synuclein triggered by presynaptic dysfunction …
Accumulation of α-synuclein triggered by presynaptic dysfunction シナプス前終末の機能異常
によるα-synucleinの集積 … シナプス前終末の機能異常によるα-synucleinの集積 …